Identification of cellular targets in the molecular interactions of antimicrobial peptides

This project aims to advance the understanding of antimicrobial peptides (AMPs) and their molecular interactions with cells. AMPs are key components of innate immunity and display broad biological activities, including antimicrobial and anticancer effects, making them promising candidates for innovative therapeutic strategies. The research focuses on temporins, a family of peptides originally identified in frog skin, whose precise molecular targets remain largely unknown. By combining chemical biology approaches with advanced analytical methods, the project seeks to identify and validate the cellular interaction partners of selected temporin peptides in microorganisms and cancer cells. This work strengthens knowledge at the interface of chemistry and biology and supports the development of next-generation bioactive molecules with potential biomedical applications.